NEWS ITEM

ZENO Identifies Key Food Components That Efficiently Reduce Alcohol Absorption

January 21, 2018


Zeno Functional Foods has completed a systematic study of the ability of snack foods, macronutrients, polysaccharide fibers, and their combinations to influence alcohol absorption and metabolism. Using an in-human case study approach, individual foods or test nutrition bars were eaten as part of a controlled testing protocol at Zeno to evaluate their ability to reduce alcohol absorption and peak blood alcohol levels as well as overall alcohol bioavailability. The protocol consisted of a subject eating a standardized lunch followed by a six hour fasting period; the test food was then consumed and a defined alcoholic cocktail (20% alcohol by volume, 0.35g alcohol/kg bodyweight, about a "double cocktail equivalent") which was finished over 10 minutes. The blood alcohol level was then estimated using a calibrated breathalyzer over the next 90 minutes with the effect of the foods eaten compared to the no food (empty stomach) condition.

The medical literature suggested, but had not proven, that certain macronutrients and fibers might influence alcohol absorption through an effect on the gastric emptying rate. The rate of gastric emptying has been established as an important influencer of alcohol absorption and first pass metabolism and because of this, was targeted as a key mechanism for the development of the SOBAR. A wide array of prepared foods were tested including chips, savory snack mixes, cheese, nuts, granola/protein/nut bars, bananas, cookies, and full meals. In addition to these foods, test nutrition bars were formulated that were high in carbohydrate, fat, or protein and combinations of these with polysaccharide fibers were evaluated. The results of this work indicated that snack bars that had particular combinations of macronutrients and fiber types were the most efficient, per calorie, on reducing peak blood alcohol levels and alcohol bioavailability.

Alco-HOLD

ZENO's unique combination of ingredients used for the purpose of reducing alcohol bioavailability has been named Alco-HOLD since its presumed mechanism of action is that of holding alcohol in the stomach for a longer period due to delaying gastric emptying. The company plans to both use this formulation in the development of the SOBAR as well as to file broadly for patent protection for these novel and important research results.


NEWS ITEM

ZENO Identifies Key Food Components That Efficiently Reduce Alcohol Absorption

January 21, 2018


Zeno Functional Foods has completed a systematic study of the ability of snack foods, macronutrients, polysaccharide fibers, and their combinations to influence alcohol absorption and metabolism. Using an in-human case study approach, individual foods or test nutrition bars were eaten as part of a controlled testing protocol at Zeno to evaluate their ability to reduce alcohol absorption and peak blood alcohol levels as well as overall alcohol bioavailability. The protocol consisted of a subject eating a standardized lunch followed by a six hour fasting period; the test food was then consumed and a defined alcoholic cocktail (20% alcohol by volume, 0.35g alcohol/kg bodyweight, about a "double cocktail equivalent") which was finished over 10 minutes. The blood alcohol level was then estimated using a calibrated breathalyzer over the next 90 minutes with the effect of the foods eaten compared to the no food (empty stomach) condition.

The medical literature suggested, but had not proven, that certain macronutrients and fibers might influence alcohol absorption through an effect on the gastric emptying rate. The rate of gastric emptying has been established as an important influencer of alcohol absorption and first pass metabolism and because of this, was targeted as a key mechanism for the development of the SOBAR. A wide array of prepared foods were tested including chips, savory snack mixes, cheese, nuts, granola/protein/nut bars, bananas, cookies, and full meals. In addition to these foods, test nutrition bars were formulated that were high in carbohydrate, fat, or protein and combinations of these with polysaccharide fibers were evaluated. The results of this work indicated that snack bars that had particular combinations of macronutrients and fiber types were the most efficient, per calorie, on reducing peak blood alcohol levels and alcohol bioavailability.

Alco-HOLD

ZENO's unique combination of ingredients used for the purpose of reducing alcohol bioavailability has been named Alco-HOLD since its presumed mechanism of action is that of holding alcohol in the stomach for a longer period due to delaying gastric emptying. The company plans to both use this formulation in the development of the SOBAR® as well as to file broadly for patent protection for these novel and important research results.